N-Cbz-L-Aspartic acid 4-benzyl ester

indexes

CAS No.: 3479-47-8

Molecular Formula: C₁₉H₁₉NO₆

Molecular Weight: 357.36

EINECS No.: 222-456-1

It is a dual-protected monomer for aspartic acid (Asp) in peptide synthesis. Its core application is to achieve precise and selective control over the reactions of the α-amino group and β-carboxyl group during the construction of aspartic acid-containing sequences.

1. Peptide Synthesis
As a dual-protected monomer of L-aspartic acid, it is widely used in solid-phase and solution-phase peptide synthesis, enabling precise control over the selective reaction of aspartic acid side-chain carboxyl groups to avoid side reactions, serving as a key raw material for peptide drugs and bioactive peptides.

2. Pharmaceutical Intermediate
Applied in the R&D and production of anti-tumor, antiviral, cardiovascular and nervous system drugs, especially for the preparation of high-end pharmaceutical intermediates such as RGD-sequence targeted drugs and aspartic protease inhibitors.

3. Organic Synthesis & Chemical Biology
Used as a chiral synthon for protein/peptide modification, enzyme inhibitor construction and synthesis of chemical biology activity probes.