Fmoc-Glycine

Fmoc-Glycine;

Fmoc-Gly-OH

CAS No.: 29022-11-5
Molecular Formula: C₁₇H₁₅NO₄
Molecular Weight: 297.31
EINECS No.: 249-373-3

Fmoc-Glycine is one of the most fundamental protected amino acids in Fmoc-solid-phase peptide synthesis (SPPS). Its main applications are:

1. Therapeutic Peptide Synthesis
As a building block for introducing glycine residues into peptide chains, it is a key intermediate for synthesizing antimicrobial peptides, antitumor peptides, GLP-1 analogs, somatostatin, oxytocin analogs and other peptide drugs.

2. Flexible Linker
With no side chain and high conformational flexibility, glycine is widely used as a linker in antibody-drug conjugates (ADCs), peptide vaccines and fluorescently labeled peptides to improve molecular compatibility and stability.

3. Cyclic Peptides & Conformational Regulation
Used in constructing cyclic peptides, β-turns and other special structures to regulate peptide conformation and enhance bioavailability and enzymatic stability.

4. Biochemical & Research Reagent
Applied in peptide library construction, combinatorial chemistry, enzyme substrates and receptor ligand development.