Fmoc-L-Phenylalanine

Fmoc-L-Phenylalanine, Fmoc-Phe-OH

CAS No.: 35661-40-6
Molecular Formula: C₂₄H₂₁NO₄
Molecular Weight: 387.43
EINECS No.: 252-661-1

Fmoc-L-Phenylalanine is a commonly used protected amino acid in Fmoc-solid-phase peptide synthesis (SPPS). Its main applications are:

1. Therapeutic Peptide Synthesis
As a core building block for introducing phenylalanine residues into peptide chains, it is a key intermediate for synthesizing antitumor peptides, antimicrobial peptides, antiviral peptides, neuropeptides, GLP‑1 analogs, peptide vaccines, etc.

2. Construction of Cyclic and Constrained Peptides
The aromatic side chain of phenylalanine can enhance conformational stability, cell membrane permeability and bioactivity of peptides via hydrophobic interactions and π‑π stacking, making it widely used in long‑acting peptide and cyclic peptide drug development.

3. Chiral Pharmaceutical Intermediate
Used as a chiral source for the synthesis of small‑molecule enzyme inhibitors, receptor ligands, analgesics and chiral drugs related to the central nervous system.

4. Biochemical Research Reagent
Applied in peptide library construction, antibody‑drug conjugates (ADC), fluorescently labeled peptides and in vitro assay substrate development.