Fmoc-L-Proline

CAS No.: 71989-31-6
Molecular Formula: C₂₀H₁₉NO₄
Molecular Weight: 337.37
EINECS No.: 276-259-0

Fmoc-L-Proline is one of the most commonly used Fmoc-protected amino acids in solid-phase peptide synthesis (SPPS). Its main applications are:

1. Therapeutic Peptide Synthesis
As a standard building block for introducing proline residues into peptide chains, it is a key intermediate for synthesizing antimicrobial peptides, antitumor peptides, antiviral peptides, GLP-1 analogs, NMDA receptor modulators, etc.

2. Construction of Cyclic & Structurally Constrained Peptides
The cyclic structure of proline favors β-turn formation, widely used in cyclic peptides to improve stability and bioactivity.

3. Chiral Pharmaceutical Intermediate
Used as a chiral source for synthesizing alkaloids, enzyme inhibitors, and other chiral small-molecule drugs.

4. Biochemical & Research Reagent
Applied in peptide library construction, antibody conjugation, enzyme substrates, and receptor ligand development.